These are examples of the types of testing Jean is likely to recommend, during the first and subsequent visits
Biomedical Profile Number 1
Although the DAN! Profile remains largely unchanged and still includes the Food Allergen Cellular (FAC) Test; Gluten Sensitivity Profile, Kryptopyrroles, Histamine, Hair Mineral Analysis, and Secretory IgA – it also now includes some improved profiles as described below:
- FAC test
- Gluten Sensitivity Profile
- Hair Mineral Analysis
- Secretory IgA
- NutrEval Profile: including Organic acids, Oxidative stress indicators, Amino Acids, Essential Fatty Acids, Toxic
- & Nutrient Elements, Homocysteine, Vitamin D.
- Comprehensive Digestive Stool Analysis with Parasitology (CDSA+P) 2.0: New improved stool analysis
- measuring improved measurement of digestion (pancreatic elastase) and inflammation (calprotectin and
- eosinophil protein X)
- Urinary Porphyrins: Measuring 6 metabolites that provide a sensitive indication of heavy metal toxicity.
- C-reactive protein (hs-CRP), a non-specific inflammatory marker, is now included in the Functional Blood
Biomedical Profile Number 2 Non Bleed
- ONE profile (first morning urine Organic Acids, Amino Acids, Lipid peroxides and new oxidative damage marker, 8-OHdG).
- CDSA + P 2.0 stool analysis.
- Hair Mineral Analysis.
- Secretory IgA.
Allergy Testing (FACT)
Although certain foods, including gluten and casein, can cause severe adverse reactions in many children with ASD, there may be other foods that these children can’t tolerate that may remain unidentified. These may produce mild symptoms that are not easily attached to any one food, as symptoms of food intolerances can often be delayed. Testing for food reactions can help identify other problematic foods, and reduce strain on digestive systems of these kids.
The FACT test measures approximately 150 foods for intolerances as well as a measure of total IgE antibodies, which can help alert you to the possibilty of food allergies as well as intolerances.
Genovations Autism Profile
The Autism Genovations Profile offers predictive genomics profiles that help to evaluate carefully selected genetic variants that provide a previously ‘unseen ‘glimpse’ into an individual’s potential future health.
Genetic differences can often confer certain advantages or disadvantages towards health, in a given environment. The Genovations Profile helps to evaluate those genetic variations or ‘SNPs’ that are modifiable through diet, lifestyle and specific nutrient supplementation.
This can allow the practitioner to develop a support programme that can potentially reduce the risk of certain ‘negative’ genetic variations to develop, by using very precise, customised interventions. In a complex condition such as Autism, the Genovations Profile can also help to inform the practitioner which specific areas are likely to need monitoring or further investigation.
- ApoE: Apolipoprotein E (ApoE) plays a key role in lipid metabolism by helping to remove dietary cholesterol from the bloodstream. This can influence the risk for cardiovascular disease, including atherosclerosis, myocardial infarction, stroke and osteoporosis. These multifunctional receptors, known to regulate cholesterol transport, and becoming increasingly interesting to the neuroscience community due to their ability to transduce a diversity of extra cellular signals across the membrane in the adult Central Nervous System. In addition, genetic, biochemical and behavioural studies have implicated these signalling systems in a number of human degenerative and neuropsychiatric disorders involving the loss of cognitive ability, such as Alzheimers disease, schizophrenia and autism. The presence of the two cysteines in APO-E2 are capable of mercury binding and therefore mercury removal from the Central Nervous System. APO-E4 differs from APO-E2 in that these two cysteines have been genetically replaced by arginines that have no mercury binding activity.
- MTHFR: Polymorphims of this enzyme can disrupt the metabolism of B vitamins (including folic acid), potentially leading to a build up of homocysteine. The presence of these SNP’s can increase the risk of cardiovascular disease, blood vessel damage, thromboses, stroke and degenerative ageing. MTHFR is a key enzyme that can facilitate remethylation.
- COMT: Polymorphisms of this enzyme may lead to impaired metabolism and impaired deactivation of certain neurotransmitters such as dopamine, epinephrine and norepinephrine, various chemicals and toxins which may predispose someone to bipolar disorders, ADHD and alcoholism.
- IL-1B: This gene affects the duration and intensity of the inflammatory response. Polymorphisms can increase the level of inflammation, which is associate with the aetiology of the autistic spectrum disorders and also increase the susceptibility to Helicobacter pylori infection.
- VDR: Impairment of the Vitamin D receptor can cause resistance to Vitamin D, leading to impaired calcium absorption, increased bone loss, lower bone mineral density, and enhanced bone lead accumulation. Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds the active form of vitamin D and interacts with target-cell nuclei to produce effects. Interacts with calcium levels, so important in ASD. Functional Vitamin D Receptor gene polymorphisms may influence modification of cell growth, protection from oxidative stress, cell-cell matrix effects, or insulin and insulin-like growth factor pathways; they are associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. Variants of the VDR have been found to be associated with immune-mediated diseases that are characterised by an imbalance in helper T-cell development, such as Crohns and tuberculosis. The results of several studies identify VDR variants as genetic risk factors for asthma and allergic diseases.
- GSTM1 & GSTP1: Glutathione (GST) detoxifies many water-soluble environmental toxins, including solvents, herbicides, fungicides, and heavy metals including mercury, cadmium, and lead.
Pre-Conceptual Care Panel
- Metabolic Analysis Profile: measuring important organic acids.
- IgG Food Intolerance screen assessing 88 different foods for IgG antibody reactions.
- Full Essential Fatty Acids screen.
- Hair Mineral Anaylis.
- Functional Blood Chemistry: a comprehensive blood chemistry and full blood count, including ferritin, thyroid function markers and now includes hs-CRP.
- Nutrient & Toxic Elements: measures red blood cell levels of important minerals and toxic metals.
- Toxic Element Clearance Profile: Usually used with a chelating agent to assess total body storage of toxic metals.
- Functional Blood Chemistry: a comprehensive blood chemistry and full blood count, including ferritin, thyroid function markers and now includes hs-CRP .